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Original images Impact of the mandatory implementation of reporting guidelines on reporting quality in a surgical journal: A before and after study. Author summary We bring experimental evidence that pre-exposure to mRNA-LNPs or its LNP component affects innate and adaptive immune responses. PLOS Pathogens will contact all authors by email at submission to ensure that they are aware of the submission. Several discrete emotions have broad theoretical and empirical importance, as shown by converging evidence from diverse areas of psychology, including facial displays, developmental behaviors, and neuroscience. 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Answers to the questions in this section are required and will be included in the decision letter to the author. PLoS ONE. Research Article. Refutation and controversy is seen across the range of research designs, from clinical trials and traditional epidemiological studies [] to the most modern molecular research [4,5].There is increasing concern that in modern research, false findings Reach. Learn More Submit Now The NC3Rs developed the ARRIVE guidelines in 2010 to help authors and journals identify the minimum information necessary to report in publications describing in vivo experiments. 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