From Wikipedia the free encyclopedia. [1] This molecule can be used as a precursor in the vanillin synthesis by biotransformation by cell cultures of Capsicum frutescens, a type of Chili pepper. Biological Activity Protocatechualdehyde (PCA) exerts anti-cancer activity through down-regulating cyclin D1 and HDAC2 in human colorectal cancer cells. 139-85-5 - IBGBGRVKPALMCQ-UHFFFAOYSA-N - Protocatechualdehyde - Similar structures search, synonyms, formulas, resource links, and other chemical information. Protocatechualdehyde (PCA) is an important plant-derived natural product that has been associated with a wide variety of biological activities and has been widely used in medicine as an antioxidant, anti-aging and an anti-inflammatory agent. Rating: 2. . FECO is basically derived from ethanol or grain alcohol whereas RSO is extracted from isopropyl alcohol. Protocatechualdehyde (PCA), a phenolic acid compound of Sm, prevents methylglyoxal-induced mitochondrial dysfunction and advanced glycation end products (AGEs)-RAGE axis activation in human lens epithelial cells (Wang et al., 2014e). Protocatechualdehyde (PCA) (50, 100 M, 24/ . Protocatechualdehyde (PCA), an important component of Salvia miltiorrhiza, has many activities, such as anti-inflammatory and antisepsis activities.However, the role of PCA in osteoclasts is not clear. Pharmaceuticals and Healthcare ICT and Media . Suggest. 138g protocatechualdehyde 120 ml 50% NaOH aqueous solution (91g NaOH, 91g dH2O) 500 ml dimethylsulfoxide (DMSO) 120ml (160g) dichloromethane (DCM). This website uses cookies to ensure you get the best experience. oxidative dimerisation of protocatechualdehyde 13 to give 17 (Scheme 5). Protocatechualdehyde; Protocatechuic aldehyde; Synonyms: 1.3 Details of the Supplier of the Safety Data Sheet: 1.2 Relevant identified uses of the substance or mixture and uses advised against: 1.4 Emergency telephone number: Section 2. Protocatechualdehyde contains phenolic hydroxyl in ortho-position, which is material base for its antioxidation. HHS Vulnerability Disclosure. Chat now for more business. Purpose: Protocatechualdehyde (PCA) is a phenolic compound found in the roots of Salvia miltiorrhiza with anti-proliferative and antioxidant activities. The compound contains pro-apoptotic and antiproliferative properties against human breast cancer cells as well as colorectal cancer cells by reducing the expression of cyclin D1 and -catenin. An annual publication of satisfactory methods for the preparation . A chemical structure of a molecule includes the arrangement of atoms and the chemical bonds that hold the atoms together. Definition of protocatechualdehyde : a crystalline compound C6H3(OH)2CHO which is synthetically prepared and the monomethyl ether of which is vanillin; 3,4-dihydroxy-benzaldehyde History and Etymology for proto catechualdehyde protocatechualdehyde International Scientific Vocabulary protocatechu ic acid + aldehyde Love words? Note: mg/kg = .001/1000 = 0.000001 = 1/1000000 = ppm. 2 votes. PAL abbreviation stands for Protocatechualdehyde. The yeast Yarrowia lipolytica naturally produces pyomelanin. DGIdb, The Drug Gene Interaction Database, is a research resource that can be used to search candidate genes or drugs against the known and potentially druggable genome. PAL means Protocatechualdehyde. We used RAW264.7 cells (a mouse leukemic monocyte/macrophage cell line) and bone marrow macrophages (BMMs) to probe the role of PCA in osteoclasts and the underlying mechanism. In vivo, the prodrug PCA restrains the destruction of the femoral condylar cartilage caused by adjuvant arthritis [ 10 ]. 2-Hydroxy-3-methoxybenzaldehyde Variety of thiazolidin-4-one ring systems having . Learn More I Agree [email protected] +918484035727 . Contact China Manufactory Hangzhou KieRay Chem Co. for the product Protocatechualdehyde. Policies. Purchase quality protocatechualdehyde powder from Alibaba.com and make a variety of healthy foods and helpful medicines. Skip to content. This review also provides a description of the biomarkers commonly used to evaluate lipid peroxidation and antioxidant defenses in experimental and human hypertension. PCA abbreviation stands for Protocatechualdehyde. 3, 4 according to reports, protocatechualdehyde has strong protein glycosylation inhibitory activity, 3, 4 and has an inhibitory effect on the formation of ages-bsa in vivo and in vitro, and can inhibit 8600 Rockville Pike, Bethesda, MD, 20894 USA. These findings suggest that upregulation of GADD45 and GADD153 proteins are the mechanism for protocatechualdehyde's Molecular Formula CHO. Synthesis Reference(s): Organic Syntheses. [2] It is also found in the mushroom Phellinus linteus. National Library of . The invention relates to a detection method for compound radix salviae miltiorrhizae dripping pills through quantitative analysis of multiple components by single marker; the method is a content determination method for six kinds of phenolic acid components through UPLC and quantitative analysis of multiple components by single marker; protocatechualdehyde is adopted as a single calibration . : 139-85-5 1.2 Relevant identified uses of the substance or mixture and uses advised against Identified uses : Laboratory chemicals, manufacture of substances. site uses cookies. Then, 4,4-diaminodiphenyl ether (19.8 g, 0.10 mol) was slowly added into this system. The hydroxychalcones which have a 3,4-dihydroxycinnamoyl structure were potent inhibitors of lipid peroxidation in rat liver microsomes. Protocatechualdehyde can improve the blood rheology index for patients with acute exacerbation of chronic pulmonary heart disease. Protocatechualdehyde treatment also induced the expression of cell cycle inhibitors p21 and p27, while inhibiting Bcl-2, cyclin D1, CDK2, CDK4 and CDK6 genes. Protocatechualdehyde market is split by Type and by Application. Protocatechualdehyde (PCA) is the main degradation product of salvianolic acid B and has many activities, such as anti-inflammatory and antibacterial properties [ 9 ]. Finally, we review the strategies (antioxidants, antihypertensive drugs) known to prevent or ameliorate oxidative damage, both in animal models of hypertension and hypertensive . The large excess of the copper salt is used to ensure a complete conversion of the mandelic acid derivative 14. MedChemExpress provides thousands of inhibitors, modulators and agonists with high purity and quality, excellent customer reviews, precise and professional product citations, tech support and prompt delivery. 1.3.2 USA Protocatechualdehyde Market Size and Growth Rate of Type 2 from 2016 to 2027. 15 one places 400g KOH and 400mL dH20 and heats it slightly with stirring to dissolve the salt. Please see the NLM Technical Bulletin article for more information. Industry Verticals. After continuous stirring for 30 min at room temperature, the system was heated to 80 C and stirred for 6 h. 1.3.3 China Protocatechualdehyde Market Size and Growth Rate of Type 3 from 2016 to 2027. 2 votes. In N 2 atmosphere, protocatechualdehyde (41.4 g, 0.30 mol) was dissolved in 350 mL of ethanol. 1565/2000 (EC, 2000) in FGE.06 (EFSA, 2002a). Previous studies have demonstrated that PCA can have an anticancer effect on multiple cancer types, but little is known about the effect of PCA on melanoma cells. Equipment used: 1L RBF & condenser (for methylenation), stirrer hotplate with oil bath 500 ml RBF (for addition mixture), stirrer mantle 500 ml mixing beaker 3L RBF & heater for steam distillation Relevant identified uses: For research use only, not for human or veterinary use. 1.4.2 China Protocatechualdehyde Market Size and Growth Rate of Application 2 from 2016 to 2027 Protection of Nerve Cells and Cerebral Ischemia Injury At present, there are few studies on protocatechualdehyde against diabetic cataract (DC), and there is also lack of systematic research on the mechanism of protocatechualdehyde. 1.4 Market Segment by Application 1.4.1 China Protocatechualdehyde Market Size and Growth Rate of Application 1 from 2016 to 2027. [3] 1.3.1 USA Protocatechualdehyde Market Size and Growth Rate of Type 1 from 2016 to 2027. 3,4-Dihydroxybenzaldehyde can be used as a reactant for the synthesis of: Copolymers containing poly ( p -phenylenevinylene) chromophore to be used in light-emitting electrochemical cell. X. ChemIDplus is moving to PubChem in December 2022. So it treats cardiovascular and cerebrovascular diseases induced by active oxygen. However, fewer reports concerning its antibacterial effects on plant-pathogenic bacteria exist. Supplier: Extrasynthese: Catalog Number: 6045: Synonym Chemical Name(s): 3,4-Dihydroxybenzaldehyde; 3,4-Dihydroxybenzenecarbonal; 3,4-DHBAOP; 3,4-Dihydroxybenzyl aldehyde; 4-Formyl-1,2-dihydroxybenzene. The gene 4HPPD, which encodes an . Rating: 2. Chemical Structure Description. For the period 2016-2026, the growth among segments provide accurate . Product name : Protocatechualdehyde Catalog No. Our study sheds light on the potential of PCA from commonly used anti-cancer Chinese herbal Medicine SJC as a lead compound targeting WT1 in the discovery . PAL stands for Protocatechualdehyde (also Programmable Array Logic and 834 more) Rating: 2. CAS: 139-85-5. ortho-Vanillin ; Names ; Preferred IUPAC name. Important Announcement. But the final product that is produced loses its aroma and strength, which leads many individuals to perceive that FECO is a superior product than any other type of cannabis extracted products. What does PCA mean? From: Medicinal Plants, 2015 View all Topics Download as PDF About this page Adrenergic (Sympathomimetic) Drugs PCA stands for Protocatechualdehyde (also Principal Component Analysis and 1164 more) Rating: 2. It has good activities for scavenging free radical. Also known as protocatechuic aldehyde, protocatechualdehyde is a naturally-occuring phenolic aldehyde that is found in barley, green cavendish bananas, grapevine leaves and root of the herb S. miltiorrhiza 1. Protocatechualdehyde (PCA), also known as 3,4-dihydroxybenzaldehyde, is a water-soluble phenolic acid compound that naturally occurs in the herb Salvia miltiorrhiza. Average mass 138.121 Da. Protocatechualdehyde related products. Food categories according to Commission Regulation EC No. Protocatechualdehyde (PCA) (50, 100 M, 24 . Protocatechualdehyde (Catechaldehyde), a natural polyphenol compound isolated from the roots of radix Salviae Miltiorrhizae, is associated with a wide variety of biological activities and has been widely used in medicine as an antioxidant, anti-aging, an antibacterial and anti-inflammatory agent. 1.3 Details of the supplier of the safety data sheet Company: MedChemExpress USA Tel: 609-228-6898 Fax: 609-228-5909 The Merck Index* Online | Protocatechualdehyde | Monograph containing literature references, physical and biological properties and relevant information Hazards Identification National Library of Medicine. So it treats cardiovascular and cerebrovascular diseases induced by active oxygen [ 9 ]. Also known as procatechuic aldehyde, protocatechualdehyde can be found in barley, grapevine, green Cavendish, and root of herb S. miltiorrhiza. In this study, we used a chassis strain optimized to produce aromatic amino acids for the de novo overproduction of pyomelanin. Shop for multiple quantities of protocatechualdehyde powder at great savings. Using the same apparatus in fig. Get supplier listing of Protocatechualdehyde and equal product . Protocatechualdehyde (PCA) is considered to be the main phenolic component of Phellinus gilvus responsible for its anticancer properties. Abbreviation is mostly used in categories: Pharmacology Pharmacy Medical. The vanillin molecule contains a total of 19 bond (s) There are 11 non-H bond (s), 7 multiple bond (s), 2 rotatable bond (s), 1 double bond (s), 6 aromatic bond (s), 1 six-membered ring (s), 1 . Protocatechualdehyde (Catechaldehyde), a natural polyphenol compound isolated from the roots of radix Salviae Miltiorrhizae, is associated with a wide variety of biological activities and has been widely used in medicine as an antioxidant, anti-aging, an antibacterial and anti-inflammatory agent [1] . Protection of?Nerve Cells and?Cerebral Ischemia Injury Search Search Interactions Search Categories; . What does PAL mean? According to the Industry the "normal" use is defined as the average of reported usages and "maximum use" is defined as the 95th percentile of reported usages (EFSA, 2002i). nc 033 | protopine(rg) | pyrocatechualdehyde | aurora 17180 | rancinamyciniv | 4-formylcatechol | nsc 22961 | akos bbs-00003254 | rancinamycin iv | protocatecualdehyde 1.3.3 USA Protocatechualdehyde Market Size and Growth Rate of Type 3 from 2016 to 2027. 2-Arylbenzothiazoles with potential application as anti-cancer agents against human colon cancer cells. Abstract Protocatechualdehyde product: Protocatechualdehyde Protocatechualdehyde - Buck - - Major Reference Works - Wiley Online Library Skip to Article Content protocatechualdehyde (pca) is a phenolic compound found in the roots of salvia miltiorrhiza with anti-proliferative and antioxidant activities. Suppliers of Protocatechualdehyde. Protocatechuic aldehyde. inhibited in PC-9 cells knocked down for GADD45 and GADD153. Skip Navigation. Protocatechualdehyde (PCA) is a main phenolic acid in the root of Salvia miltiorrhiza Bunge (Lamiaceae), a traditional Chinese medicine widely used in the treatment of cardiovascular diseases and ischemic stroke ( Ji et al., 2000; Guo et al., 2022 ). PROTOCATECHUALDEHYDE chembl:CHEMBL222021 Alternate Names: PROTOCATECHUALDEHYDE 3,4-DIHYDROXYBENZALDEHYDE Drug Info: : HY-N0295 CAS No. FOIA. Department of Health and Human Services. 2 votes . 1.4 Market Segment by Application National Center for Biotechnology Information. average usage . 3,4-dihydroxybenzaldehyde. PCA means Protocatechualdehyde. Monoisotopic mass 138.031693 Da. Manufacturer/Factory; ISO 9001, ISO 9000, ISO 14001, ISO 14000, ISO 20000, OHSAS/ OHSMS 18001, IATF16949, HSE, ISO 14064, QC 080000, GMP, BSCI, BRC, QHSE, HACCP, ISO . Compound Protocatechualdehydewith free spectra: 7 NMR, 7 FTIR, 1 Raman, 1 UV-Vis, and 6 MS. Pyrocatechol Protocatechualdehyde Pyrocatechol Protocatechualdehyde To proceed one can merely throw all the ingredients into a reaction flask and reflux for 5 hours or one can do the more prudent way as follows. PCA suppressed transcription activity of Wnt/-catenin pathway in WT1-dependent manner. 2 votes . Our products have been widely used in more than 120 countries, mainly from the United States, Canada, the United Kingdom, Russia, Australia, Japan, South Korea, Thailand, Singapore, Vietnam . Docking experiment revealed that protocatechualdehyde (PCA) might be the active component of the herb. The inhibition of cell viability and apoptosis by PCA may be result of ATF3 expression through ERK1/2 and p38-mediated transcriptional activation. Abbreviation is mostly used in categories: Medical Pharmacology Pharmacy. ChemSpider ID 8438. Download Citation | On Apr 28, 2003, Johannes S. Buck and others published Protocatechualdehyde | Find, read and cite all the research you need on ResearchGate It has good activities for scavenging free radical. protocatechualdehyde manufacturers/supplier, China protocatechualdehyde manufacturer & factory list, find best price in Chinese protocatechualdehyde manufacturers, suppliers, factories, exporters & wholesalers quickly on Made-in-China.com. Suggest. A number of hydroxychalcones were synthesized to evaluate their protective effects against oxidative cell damage and the production of superoxide anion. Protocatechualdehyde contains phenolic hydroxyl in ortho-position, which is material base for its antioxidation. In particular, we found that 2',4',3,4-tetrahydroxychalcone (3) exhibited a potent inhibitory effect on . Protocatechualdehyde (PCA) is a main phenolic acid in the root of Salvia miltiorrhiza Bunge (Lamiaceae), a traditional Chinese medicine widely used in the treatment of cardiovascular diseases and ischemic stroke ( Ji et al., 2000; Guo et al., 2022 ). We have therefore developed a different procedure involving a two-liquid system (water:ethyl acetate) and the use of a 3-fold excess of CuCl2 and HCl under nitrogen. Protocatechuic aldehyde Protocatechuic aldehyde is a phenolic aldehyde, a compound released from cork stoppers into wine. A process for preparing protocatechualdehyde or a 3-alkoxy-4-hydroxybenzaldehyde which comprises subjecting catechol or a 2-alkoxyphenol to reaction with glyoxylic acid in a basic aqueous medium in the presence of a catalyst containing one or more compounds selected from aluminium oxide, silicon oxide and hydrated aluminium oxide in an amount of not less than 0.01 g per 1 g of the starting . Aug 22, 2022 (The Expresswire) -- Global Protocatechualdehyde Market (2022-2028) includes Precise company profiling of leading players of the. Protocatechualdehyde (Catechaldehyde), a natural polyphenol compound isolated from the roots of radix Salviae Miltiorrhizae, is associated with a wide variety of biological activities and has been widely used in medicine as an antioxidant, anti-aging, an antibacterial and anti-inflammatory agent [1]. 3,4-Dihydroxybenzaldehyde synthesis grade; CAS Number: 139-85-5; EC Number: 205-377-7; Synonyms: Protocatechualdehyde; Linear Formula: (HO)2C6H3CHO; find Sigma-Aldrich-419370 MSDS, related peer-reviewed papers, technical documents, similar products & more at Sigma-Aldrich . Contact. Other prevalent methods of extraction use CO2 and hash oil. In streptozotocin induced diabetic rats, oral administration of PCA for 8 weeks obviously ameliorated the development of diabetic cataract ( 10 ). National Institutes of Health. This pigment accumulates in the extracellular environment following the autoxidation and polymerization of homogentisic acid, a metabolite derived from aromatic amino acids.
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